Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

A clinical study on the efficacy of minoxidil liniment in treating female pattern hair loss

Chen Bin , Gao An-qiong, Yao Shuang, Liu Ya-yuan

Department of Dermatology, Lujiang County People's Hospital of Anhui Province, Lujiang 231500, China;

For correspondence:- Chen Bin Email: binei32975@163.com

Accepted: 02 December 2023 Published: 31 December 2023

Citation: Bin C, An-qiong G, Shuang Y, Ya-yuan L. A clinical study on the efficacy of minoxidil liniment in treating female pattern hair loss. Trop J Pharm Res 2023; 22(12):2483-2488 doi: 10.4314/tjpr.v22i12.9

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the clinical effect of low and high-dose minoxidil liniment in treating female pattern hair loss.

Methods: A total of 280 female pattern hair loss patients admitted to the dermatology clinic of Lujiang County People's Hospital of Anhui Province, China from October 2020 to October 2021 were randomly divided into control and study groups comprising 140 patients in each group. Ludwig staging in the two groups included 35 cases of Type I, 80 cases of Type II, and 25 cases of Type III in control group; 40 cases of Type I, 74 cases of Type II, and 26 cases of Type III in study group. Control group was treated with 1 mL (7 sprays) of 2 % minoxidil liniment, twice daily for 6 months. Study group was treated with 1 mL (7 sprays) of 5 % minoxidil liniment. Efficacy of low and high-dose minoxidil liniment was determined according to the area and degree of hair loss before and after treatment, and the incidence of adverse responses was recorded.

Results: After treatment for 3 months, the effective rates of control and study groups were 34.3 and 41.4 %, respectively. Effective rates of control and study groups were 57.1 and 72.9 % respectively after 6 months of treatment. The effective rate of 5 % minoxidil significantly improved compared to 2 % after treatment for 6 months in Ludwig type III.

Conclusion: Both 2 and 5 % minoxidil liniments demonstrate clinical efficacy in female pattern hair loss in a dose-dependent manner.

Keywords: Minoxidil, Liniment, Female pattern hair loss